南雲 紳史教授
- Affiliation
- Department of Chemistry and Life Science, School of Advanced Engineering
Graduate School of Engineering, Department of Applied Chemistry and Chemical Engineering
Graduate School of Engineering, Department of System Design
- Laboratory
- Synthetic Organic Chemistry Laboratory [Hachioji]
- Research Keywords
- Natural product synthesis/Drug synthesis/New reaction development
- Topics of Research
- Chemical synthesis of anticancer drugs and antibiotics
Development of highly selective synthesis of cis-alkenes, development of tandem- cyclization reactions, etc.
- Related "Sustainable Development Goals (SDGs)"
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[Undergraduate] Developing new and excellent reactions
Application to the synthesis of natural organic compounds that are only available in small quantities
The ultimate goal of the study of organic synthetic chemistry is to be able to quickly synthesize large quantities of only the desired compounds. However, current organic chemistry has not yet reached that level. We aim to find better organic synthesis reactions by honing our observational skills in experiments and cultivating the ability to infer what is happening in the reaction vessel. So far, we have developed continuous cyclization reactions using Lewis acids and selective synthesis reactions of thermodynamically unstable Z-alkenes. We are currently using these reactions to chemically synthesize natural organic compounds with useful pharmacological activity. We are also discovering new reaction developments one after another.
[Graduate School] Synthesizing complex natural products using reactions developed by the student
In developing new types of pharmaceuticals, it is very important to find compounds with useful biological activity. Searching for organic compounds (natural products) produced by plants and bacteria is a powerful means for this purpose. At the same time, it is also important to chemically synthesize such natural products, but many compounds have very complex structures and are difficult to synthesize by simply combining existing reactions. For this reason, we overcome the problems we face in actual synthesis by developing new reactions with our own hands, and by steadily continuing such efforts, we are challenging the chemical synthesis of natural products.
